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Significantly, enhanced transamination and aspartate synthesis in K-Ras-driven cancer cells are important in the promotion of nucleotide biosynthesis 184 and maintenance of redox balance 29

For example, in glutamine-addicted clear cell renal cell carcinomas, the competitive consumption of glutamine by tumor cells results in local deprivation of extracellular glutamine, which activates HIF-1 and induces tumor-infiltrating macrophages to secrete IL-23

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To confirm this finding, we selected tubular ER markers based on published RNA sequencing data (Supplementary Fig 1c) and conducted immunohistochemistry on spinal cord cross-sections from P14 mice

Thus, the observations noted here concur with others in that the MOx treatment increases the yield of stabilized pigment from carbonyl reactions, while sulfite decreases their yield