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In GBM studies, Metformin is believed to potentially exert its anticancer effects by regulating cellular metabolism, influencing tumor cell proliferation, apoptosis, and other pathways [14, 15]

Moreover, certain probiotics aid in weight management by stimulating the adrenergic nervous system to trigger thermogenesis

doi: 10.1016/j.pharmthera.2017.05.013

The TRAVERSE trial confirmed cardiovascular non-inferiority, but flagged atrial fibrillation and kidney injury signals that demand ongoing monitoring

Such trials are necessary to determine whether the promise shown in preclinical research translates to meaningful human benefit and to establish safe, effective dosing protocols