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Mitochondrial Dysfunction as a Force Multiplier Mitochondria act as both generators and sensors of oxidative stress, amplifying redox imbalance and accelerating cellular dysfunction across metabolically active tissues

Rats were survived for 5 additional days to allow for maximal retrograde transport of the tracer FG to the perikaya of spinal motor neurons, and sacrificed under deep anesthesia by transcardial perfusion with saline and subsequently buffered 4% paraformaldehyde

230 Effective neuromuscular control relies on the precise regulation of ion channels and neurotransmitter release at the neuromuscular junction, which are modulated by molecular mechanisms

2019;29:27312744.e2734

Burk RF, Hill KE, Motley AK, Winfrey VP, Kurokawa S, Mitchell SL, Wanqi Zhang W

Christensen, K., Frederiksen, H