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APS could down-regulate inflammation-related pathway proteins and cytokines in vitro and in vivo , such as a series of pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-), interleukin-1beta, interleukin-6, interleukin-18, cyclooxygenase-2, and monocyte chemoattractant protein-1 (MCP-1/CCL2), which up-regulate anti-inflammation cytokine interleukin-10 (Sun et al., 2019

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they require oxygen and nutrients delivered through blood vessels, just like every other tissue