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10.1200/jco.2019.37.15_suppl.2523 251

Systemic administration typically suits joint applications given the difficulty of accessing intra-articular spaces without specialized medical procedures

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101 Despite major advances in the acknowledgment of tissue-specific NAD + homeostasis, further work will be needed to fully characterize the subcellular and systemic modulation of NAD + metabolism, which can improve the preventive and therapeutic strategies based on maintaining healthy NAD + homeostasis

We harmonized the %F values and evaluated all chemical structures to ensure that the data in our database is accurate