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Nat Chem Biol (2017) 13(1):918

Oral supplements face a major hurdle stomach enzymes break down glutathione before absorption

Several authors have shown that high doses of vitamin E can also interfere with drug metabolism ( In the HOPE study, supplementation of 400 IU (=268 mg) of vitamin E/day in mild to moderate CKD patients has no effect on cardiovascular outcomes and overall mortality and therefore supplementation of vitamin E is not recommended (HOPE Study Investigators, 2000)

Cai Z, Zhao B, Ratka A

Why does the dose increase in the second half of the cycle