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Vitamin B12 supplements are recommended to population groups at higher risk for developing vitamin B12 deficiency: everyone (no matter what their diet) over 50 years old, people with diseases of the gastrointestinal system such as Chrohns and IBS, women on oral contraceptives and people who regularly use nitrous oxide or are alcoholics

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doi: 10.1136/pmj.79.930.218

Moderately low serum B12 concentrations between 148 or 150 and 221pmol/L or 260pmol/L are often considered indicative of depleted or subclinical B12 deficiency

Research in older populations The majority of human research on epitalon has been conducted in elderly populations, typically ages 60 to 80

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