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To survive under these conditions, malignant cells extensively reprogram proteostasis networks

antioxidant potential, physiological function and role in disease

Nature 2016;532:255-8

Again, this points to controlling inflammation which is toxic to astrocytes

DOI: 10.1111/j.1749-6632.1994.tb56847.x 10

Overall, hormonal imbalances like with fluctuations in testosterone levels can disrupt the delicate balance of factors that maintain clear and healthy skin, leading to increased sebum production, changes in skin cell turnover, inflammation, and acne formation