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This genotype also had higher catalase (CAT), superoxide dismutase (SOD), remarkable and dramatic increment in ascorbate-glutathione content, ascorbate-glutathione redox and ascorbate-glutathione cycle enzymes activity compared to sensitive genotype VA15

Identification of novel substrates for the serine protease HTRA1 in the human RPE secretome

The antioxidant system involved in the defense against ferroptosis is mainly controlled by the transcription factor nuclear factor erythroid-2-related factor (NRF2), which is known to induce the expression of antioxidant enzymes and lipid detoxification enzymes [46]

K., Brennan III, W

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With this form of the disease, new abnormal blood vessels grow under the retinal pigment epithelium, under the retina, or even within the retina