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10.1038/s41467-025-61894-9 138 LuL.XuW.FengL.TengX.BanW.XueY.et al (2024)

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One way to circumvent this problem is the delivery of therapeutic genes encoding intracellular enzymes for the conversion of a prodrug to a cytotoxic drug which can then spread to neighboring non-transduced cells (bystander effect)