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F2 is an integral component of the clotting process and other studies of both type 1 and type 2 diabetic individuals have reported high coagulation factor levels, including F2 [41]

Zhang J, McCastlain K, Qu C, Wu G, Edmonson M, Li Y, Wei L, Payne-Turner D, Yoshihara H, Churchman ML, Waanders E, Ntziachristos P, Aifantis L, Roberts KG, Ma J, Song G, Easton J, Mulder HL, Xiang C, Rusch M, Boggs K, Vadodaria B, Dalton J, Valentine ML, Ding L, Lu C, Fulton RS, Fulton L, Tabib Y, Ochoa K, Devidas M, Pei D, Cheng C, Evans WE, C-H P, Jeha S, Harvey RC, Chen I-M L, Willman CL, Marcucci G, Bloomfield CD, Kohlschmidt J, Mrozek K, Paietta E, Tallman MS, Stock W, Voorhees PM, Racevskis J, Rowe JM, Luger S, Kornblau SM , Shurtleff SA, Raimondi SC, Mardis ER, Wilson RK, Hunger SP, Loh ML, Down JR, Mullighan CG

Alternatively, in case an HBGV could not be calculated due to uncertainty, or, in case the compound is genotoxic and carcinogenic, the point of departure (POD) is used

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The principal reason for UC is increased oxidative stress caused by increased ROS production and reduced SOD concentrations

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