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1162 In patients with dilated cardiomyopathy and myocardial ischemia, trimetazidine has been shown to increase the left ventricular ejection fraction, 1163 indicating a direct positive impact on cardiac function

PMID: 8751466

Thus, estrogen depletion would be associated with withdrawal of inhibitory tone such as that imparted by the parasympathetic system thereby increasing peripheral resistance and lowering heart rate variability