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CD38_targeting monoclonal antibodies (mAbs), including daratumumab (DARA) and isatuximab (ISA), exert antitumor activity through direct cytotoxicity and immune modulation

Some sources suggest subcutaneous injection provides more reliable absorption

- Hydroxocobalamin offers a longer-lasting effect and is more suitable for therapeutic use

doi: 10.1080/00365510050184994

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To test this hypothesis, we first validated the RNA-seq results by RT-qPCR experiments: cytosolic RPGs ( RPS6A / RPS6B , RPS22A , RPL38 , RPL31A ), as well as a mitochondrial RPG ( MRPL50 ), were significantly downregulated in the context of V-ATPase-dependent autophagy ( Fig