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In the absence of synthesis of GSH in the transulfuration pathway, the effects of heme-oxygenase in the first step toward heme synthesis would be expected to lead to increased downstream porphyrin synthesis and heme formation

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doi: 10.3389/fimmu.2026.1704717 Received 13 September 2025 Revised 05 January 2026 Accepted 14 January 2026 Published 02 February 2026 Volume 17 - 2026 Edited by Pankaj Dipankar, National Institutes of Health (NIH), United States Reviewed by Shanid Mohiyuddin, University of Missouri, United States Diego Salazar, National Institutes of Health (NIH), United States Updates Copyright 2026 Lv, Cao, Zhao, Yang, Ma, Zhang, Wu, Chen and Gao

The bottom line on body composition is that neither treatment shows a clear advantage over the other based on available data