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For most adult applications, volumes around 100150 L per nostril are recommended to balance drug retention/deposition with minimal nasal irritation, and many pumps meter 50100 L per actuation (Chung et al., 2023, Trevino et al., 2020)

Typically administered intramuscularly

However, systemic copper loading remains a theoretical concern requiring careful dose optimization and copper status monitoring, particularly with chronic administration protocols

Full assessment is required prior to injecting

While colposcopy can detect low- and high-grade dysplasia, its sensitivity for identifying microinvasive lesions remains limited

This study also didnt address the affordability of drinking water, or the disproportionate burden that water insecurity places on the women often tasked with fetching water when its not available at home