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Dysregulation of glucose metabolism promotes protein glycation and the formation of advanced glycation end-products, which exacerbate the A-induced neuronal toxicity and oxidative stress in experimental models [29, 30]

7.4 Aloe vera The results of a double-blind, randomized clinical trial on melasma patients revealed a 32% improvement in the MASI score for the liposomal aloe vera gel group, while only a 10% improvement was obvious for the conventional aloe vera gel group ( 7.5 Vitamin C The safety and efficacy of topical vitamin C nanosome with iontophoresis was evaluated through a single-blind clinical study and results were compared with 70% glycolic acid chemical peel in patients with melasma

Additionally, according to fluorescent imaging, neutrophil membrane-coated NPs accumulate more specifically at the tumor site than control NPs [200]

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It was confirmed from different experimental studies that brucine has a gastro-protective effect, mediated via anti- H