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So much is unknown

Vitamin B12 deficiency results in megaloblastic anemia, GI lesions, and neurologic damage that begins with an inability to produce myelin and is followed by gradual degeneration of the axon and nerve head

While seemingly straightforward, the argument for stimulating or inhibiting lipolysis can be made (Table 1)

B vitamins are the stress vitamins and can help with energy, mood, focus, reducing carb cravings, and helping with detox pathways (methylation) in the body

IL-1 and cyclooxygenase-2 (COX-2) play a detrimental role in adipose tissue dysfunction in obesity [76]

However, as the science surrounding aging and metabolism continues to evolve, clinicians are discovering ways to amplify and extend those benefits