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Breach in intestinal permeability is mediated by the microbiota To further examine the link between the arthritis-related immune response, changed microbiota and intestinal epithelial barrier dysfunction, we applied different immunization protocols including (i) arthritogenic collagen type II + complete Freunds adjuvans (CII + CFA), (ii) denaturized CII + CFA (deCII + CFA) and (iii) CII without CFA (CII)

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And also consider a handler or someone you trust to help you hold your dogs while youre giving the injection