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However, it is possible that structural analogues of LCS3 that lack a nitro group are not metabolized by NQO1 and consequently fail to generate ROS via redox cycling and thus do not exhibit activity in cell-based experiments

10.3390/nu12092581 [PMC free article: PMC7551875] [PubMed: 32854403] [CrossRef] Hautanen V, Toimela T, Paparella M, Heinonen T (2023)

10.1016/j.toxlet.2017.07.215 Toxicol

for the Alliance for Clinical Trials in Oncology

Upon binding to arginine, SLC38A9 activates mTORC1 in a v-ATPase- and LAMTOR-dependent manner (Jung et al., 2015

To determine the amount of AA retained in the skin layers, epidermis (EP) was separated from dermis (D) after immersion of the skin in water at 52 C for 30 seconds