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The combination of NNC with D-threo-PPMP (PPMP), a UDP-glucose ceramide glucosyltransferase(UGCG) inhibitor, further improved the antitumor activity of MAPKi in melanoma models [61]

Cardiovascular effects of incretins - focus on GLP-1 receptor agonists

doi:10.1111/jcmm.17348 [44] Patel RH, Mohiuddin SS

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As Kojima and Kangawa, 2005 describe for the entire ghrelin system, the occupied receptor activates phospholipase C (PLC), which releases inositol trisphosphate (IP3)