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In addition, Abdelzaher et al

Collectively, these findings indicate that, under defined pathological and catalytic conditions, GSH can be repurposed from an antioxidant safeguard into a redox driver that amplifies oxidative stress and promotes cell death in tumor and inflammatory contexts

WT-expressing cells were included as a positive control for staining, with an average of ~80% of GFP-positive/p53-positive cells staining positive for pAB-1620 (Fig

Without enough glutathione, the thyroid gland can become a "battleground" of sorts

Proteins, lipids, and DNA of hepatocytes are among the cellular structures that are primarily affected by the oxidant and antioxidant imbalance within the cell, which participates in the course of inflammatory, metabolic, and proliferative liver diseases

Methods: We retrospectively identified patients with HCC who received 1 of 5 ICI regimens indicated for HCC, patients with various non-HCC cancers who received the same ICI drugs, and HCC patients who received sorafenib between 2010-2020