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128 Notably, inhibiting lactylation at K215 and K224 on canopy FGF signaling regulator 3 (CNPY3), a key regulator of protein folding in the endoplasmic reticulum, compromises the formation of the CNPY3 complex with auxiliary molecular chaperones for protein folding and lysosomal transport, thereby affecting its cellular localization and promoting lysosome rupture and pyroptosis in prostate cancer cells

A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl()/H(+) transport cycle

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Relevant role of neutrophils in oxidative stress

LBP at doses of 50, 100, and 200 mg/kg all significantly increased SOD and glutathione GSH-Px activities while reducing MDA content, effectively alleviating bisphenol A (BPA)-induced spermatogenic damage in mouse testes and significantly increasing testicular and epididymal weights

10.1242/jeb.243407 219 RegoliF.GiulianiM