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Damiano G, Rinaldi R, Raucci A, Molinari C, Sforza A, Pirola S, et al

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Class 4 shows very mild or no deficiency of the G6PD enzyme

The exclusion criteria were BMI 30, HIV-positive status, irregular menstrual cycle, pregnancy or breastfeeding in the past 6 months, COC/hormone use in the past 4 years (controls), use of COC formulations other than DRSP/EE, use of COC for less than 3 months, self-reported indications of diabetes, liver or kidney disease, asthma, other chronic diseases, chronic medication use, and smoking more than 5 cigarettes/day

Meanwhile, the knockdown of MKL-1 expression further reduced the level of GSH in cells, from 0.610.07 in the control group to 0.310.06

Unlike an additive effect (1+1=2), synergy produces a result of the type 1+1=3