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We were also able to activate JNK using C2-ceramide (Supplementary Fig

Prevention of PIN1-MAT1A interaction increases MAT1A levels in mitochondria and protects against alcohol-promoted mitochondrial malfunction and fat storage

Psoriasis: Classical and emerging comorbidities

As NAC and GSH are thiol group (-SH)-containing antioxidants, apart from directly neutralizing ROS, they also provide precursors for endogenous GSH synthesis including cysteine, glutamine and glycine under the regulation of NRF2 (Nuclear Factor, Erythroid 2 like 2), the master gene regulator responding to cellular oxidative stress, and GCLC (Glutamate-cysteine ligase catalytic subunit), and the first rate-limited enzyme in cellular GSH biosynthesis [17, 18]