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During the metastatic cascade, millions of tumor cells detach from the primary tumor, but very few of them (less than 0.02%) can survive and effectively form growing metastatic foci 4

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(2016) 167:146980.e12

Although the exact functional implications of these genera remain to be fully elucidated, Megamonas is associated with carbohydrate fermentation and short-chain fatty acid (SCFA) production, and its shift could influence host energy metabolism and immune modulation in an estrogen-deficient environment

Figure 7 GPX8 Was Highly Expressed and Influenced the Migration and Invasion of GBM Cells To confirm the function of GPX8, we selected GBM as a typical type of human cancer for further investigation