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As an example, miRNA181a/b have the capacity to influence mitochondrial biogenesis and quality control, respiratory chain assembly and mitochondrial antioxidants, with downregulation of miRNA181a/b found to be neuroprotective in mitochondrial disorders with neurodegeneration, suggesting a broad gene-independent therapeutic potential for diseases with mitochondrial dysfunction, such as PD (Indrieri et al., 2019)