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Following this observation, they also show that recovering physiological levels of this modification by treatment with the histone deacetylase inhibitor SAHA restores the expression of learning-induced genes and the cognitive abilities of old mice

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Andropause: clinical implications of the decline in serum testosterone levels with aging in men

When the SH-groups of enzymes are not maintained in a reduced form, they become inactivated

This multi-layered regulatory mechanism weakens the differentiation of naive T cells into anti-tumor Th1 cells while promoting their differentiation into pro-tumor Th2 cells