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doi: 10.3390/cells11233927 125

Moreover, leonurine exerts potent cardioprotective effects by either increasing the level of p-PIK, p-AAKT, p-GSK3 and Bcl-2, or decreasing the levels of caspase 3, cleaved-caspase3 and Bax (Xu et al., 2018)

Y.KsiazekM.NguyenK

Funding This publication is solely financed by the Wroclaw University of Environmental and Life Sciences

Cancer Tmmunol

FIGURE 3 3.3 Effects of FEV knockdown on cellular senescence and ferroptosis To further clarify whether FEV affects HUVEC senescence through ferroptosis, the researchers used RNA interference (RNAi) to knock down the expression of FEV (Figure 4A), and then assessed the senescence by -gal staining