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Therefore, the C/D ratio is a simple but effective tool to identify patients at risk of an unfavorable outcome

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Therapeutic strategies targeting MDSCs Metabolic targeting in MDSCs MDSCs display high metabolic reliance and undergo extensive metabolic reprogramming in the TME to adapt to harsh conditions, such as hypoxia, oxidative stress, and nutrient scarcity (6)

For example, the Se-containing polysaccharide SeGLP-2B-1 disrupts the mitochondrial membrane potential and enhances the cytosolic Cyt-c levels and the activity of caspases 9 and 3 [300,301]