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This stable E GSH observed in the nucleus and nucleoli throughout the cell cycle has important implications for cellular redox homeostasis, as these compartments host critical processes such as DNA replication, transcription, and ribosome biogenesis, all of which require finely tuned redox regulation

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They scavenge active radicals to inhibit chain initiation and break chain propagation reactions

Drugs can also regulate the SSP pathway by affecting the post-translational modification of key enzymes, thereby exerting tumor suppressor effects