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Common symptoms of multiple sclerosis include: Fatigue , often described as overwhelming or bone-deep Numbness or tingling , especially in the face, arms, legs, or torso Muscle weakness or loss of coordination in one or more limbs Balance problems or dizziness (vertigo-like symptoms) Blurred or double vision , sometimes with eye pain (optic neuritis) Brain fog , memory lapses, or slowed cognitive processing Bladder or bowel dysfunction , including urgency or incontinence Muscle stiffness or spasms (spasticity), especially in the legs Depression or mood swings , sometimes unrelated to situational stress Heat sensitivity , which can temporarily worsen symptoms (Uhthoffs phenomenon) Speech or swallowing difficulties , in more advanced stages During menopause, many women with MS notice a worsening of fatigue, cognitive symptoms, and sleep disruption , partly due to estrogens withdrawal and increased inflammation

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Interestingly, the NCT02158936 study investigated the efficacy of 5-Aza (75 mg/m 2 subcutaneously once daily for 7 days every 28 days) in combination with the thrombopoietin receptor agonist eltrombopag (50 mg, 100 mg, or 200 mg) as a first-line treatment strategy for MDS patients with thrombocytopenia

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PINK1/Parkin-mediated mitophagy promotes apelin-13-induced vascular smooth muscle cell proliferation by AMPK and exacerbates atherosclerotic lesions