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The rationale is theoretical and based on mitochondrial effects

In addition, S1PR3 demonstrated a strong positive connection with immune cells, exhibited excellent specificity and sensitivity, and was up-regulated in the synovium of RA patients, thus qualifying it as a biomarker for the early detection of RA [53]

2025 Nov 17;16(1):10060

Hand-searching of reference lists on key papers and web-based search of the grey literature, such as Google Scholar and professional and government websites were performed with the same terms used for the published articles

Redox Biol 59:102550102550

Currently, there is a significant gap in such studies for these combinations, which hinders the optimization of dosing regimens, prediction of drug interactions, and understanding synergistic or antagonist effects of the agents