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Its relevance to exercise and aging has recently attracted attention, as glycine availability declines with age, potentially contributing to impaired muscle repair, reduced metabolic flexibility, and increased oxidative stress ( Clinical studies examining direct supplementation are limited, but glycine's involvement in glutathione synthesis suggests a protective effect against exercise-induced oxidative stress

Reduction of antigen-induced respiratory abnormalities and airway inflammation in sensitized guinea pigs by a superoxide dismutase mimetic

However, ablation of VEGFR-1 signaling can reverse the abnormal TME associated with obesity and reprogram TAMs to promote their acquisition of the M1 phenotype

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564 HO-1 and GPX4 were downregulated due to Nrf2 defects in astrocytes, leading to increased mitochondrial fragmentation, DNA oxidation, and lipid peroxidation in mouse astrocytes, 564 suggesting that Nrf2 deficiency promotes ferroptosis in astrocytes in AD mice