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In lipid metabolism, overexpression of sphingomyelinase (SMase) may increase ceramide production, which has been implicated in the activation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) signaling, ultimately contributing to trophoblast apoptosis (25)

[DOI] [PMC free article] [PubMed] [Google Scholar] 130.Yaacov A., Cohen G.B., Landau J., Hope T., Simon I., Rosenberg S

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Xie, Z., Zhao, Q., Wang, H., Wen, L., Li, W., Zhang, X., et al., Poultry Sci