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2023;16(8):dmm050170

50 The microbiota plays a crucial role in various biological functions of the host, including the development of the immune system, protection from harmful microorganisms, food breakdown during digestion, and production of micronutrients and bioactive compounds

Metabolic diseases are becoming increasingly common in modern society, such as diabetes, NAFLD, and non-alcoholic steatohepatitis (NASH) due to people's lifestyles and irregular circadian rhythms [96]

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Many animal studies have reported that glutathione exerts an agonistic effect on NMDA receptors.8791 However, in the presence of uncontrolled and persistent chronic oxidative stress, glutathione level is decreased and leads to NMDA receptor dysfunction.9293 Deficits in glutathione level are associated with neurological deficits in various neuropsychiatric diseases.94 Glutathione regulates redox-sensitive sites such as the NMDA receptor