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7.1 Large-scale randomized controlled trials Current clinical trials are predominantly constrained by insufficient sample sizes, single-center designs, and short intervention durations

10.1007/s10157-012-0719-y 195 TsuboiN.UtsunomiyaY.HosoyaT

Furthermore, AS-IV blocks NF-B from entering the cytosol and hinders the inactivated inhibitor of NF-B (IB) to drive LPS-induced NF-B p65 overexpression, thereby effectively inhibiting cardiac hypertrophy and the fibrosis of LPS-induced H9C2 cells (47)