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Keywords: diabetic peripheral neuropathy, diagnostic markers, pathogenesis, diabetes mellitus Introduction More than 50% of people with diabetes will develop diabetic neuropathy, which is one of the most common and troublesome complications of both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM)

Various studies targeting ER stress signaling pathways and components of the UPR have demonstrated that CHAC1 expression is upregulated downstream of the ATF4-dependent signaling pathway (Figure 4)

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