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However, their clinical benefits remain modest and variable, and their use is associated with safety concerns such as amyloid-related imaging abnormalities (ARIA), costly treatment, and invasive administration routes

Frequently, the intraocular pressure lowering agents showed discordant effectiveness

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Furthermore, the depletion of glucocorticoids, through removal of the adrenal gland, resulted in an increase in adult hippocampal neurogenesis and removed stress-induced suppression of cell proliferation in the hippocampus [145]

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That the agency is investing public resources to review a compound whose own advocates withdrew their endorsement underscores the difficulty of the regulatory position these peptides occupy