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Wikipedia Insulin-like Growth Factor 1 (IGF-1) Comprehensive overview of IGF-1 biology, receptor interaction, and cellular signalling

In high amounts, that extracellular NAD can act as a danger signal, prompting your immune system to respond as if your cells were damaged

Ma L, Li Y, Peng J, Wu D, Zhao X, Cui Y, et al

Environ Heal Perspect 110(Supp (1)):103112 Kode A, Yang S-R, Rahman I (2006) Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells