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The lactone is hydrolyzed to 6-phosphogluconate, which is then oxidatively decarboxylated to ribulose-5-phosphate, an isomer of ribose-5-phosphate

After proliferation submerged culture condition, the first-passage HAECs were seeded in 12-well Transwell plates as previously described (39, 45)

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IDO-1 is found in various immune cells, including dendritic cells and macrophages, where it suppresses immune function by depleting tryptophan an amino acid vital for T-cell activity and generating immunosuppressive byproducts such as kynurenine