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When physical or chemical stimulation, antibiotic use, stress, and other reasons cause intestinal mucosal destruction, flora shift/imbalance, and inflammatory substances, through various signaling pathways (such as TLRs) to stimulate the body to produce various inflammatory mediators (such as IL-6 and TGF-, etc.), at the same time, various immune cells (such as Tregs and MDSCs) can be recruited into TME

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This results in a lower number of nave T cells and decreased T-cell receptor diversity 86

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