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Transcripts of genes implicated in PI3KAKTmTOR signaling were also increased in arrested CD8 + T cells compared to unstimulated conditions, and many of these genes elevated to higher levels in released cells compared to non-arrested cells (Fig

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For example, localisation of NOX4 with the AT1 GPCR in caveolin rafts has been shown to be essential for angiotensin II signalling and extends the concept that ROS handling enzymes are integral to certain cellular signalling machineries [66]

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