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Finally, THAP11 deficiency (Quintana et al., 2017) and ZNF143 deficiency (Pupavac et al., 2016) also affect the transcriptional regulation of MMACHC

BMI 30 : Must also have heart failure, uncontrolled high blood pressure, or chronic kidney disease

[] These findings establish the DNMT1MGST1 axis as a critical epigenetic regulator of mitochondrial integrity and cell survival post-I/R, offering novel therapeutic targets for improving graft outcomes