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The same is true for GLP-1 drugs , such as Ozempic and Wegovy , which are now widely prescribed to treat type 2 diabetes and obesity

This isn't because 1:1 is mechanistically optimal in some provable way it's because researchers studying combinations of these compounds chose 1:1 as the default and the literature accumulated around that choice

Individuals with Poor Absorption: People with low stomach acid, or those who have had certain surgeries (like gastric bypass), may struggle to absorb B12 from food and would benefit from injections