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It was discovered in the 1990s by Croatian researchers studying gastric protective factors

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(or 0.16 g/mL per-oral) given concurrently with 12.5 mg/kg/day diclofenac in Wistar rats directionally counteracted diclofenac-induced gastric, intestinal, and hepatic lesions and reduced elevations in bilirubin, AST, and ALT though the abstract does not report numeric magnitudes or p-values

The healthcare systems vary across countries, and nutritional deficiencies such as folate, iron, and zinc coexist with B12 deficiency in some parts of the world, suggesting that country-specific recommendations might still be useful, especially in settings with low resources