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Consequently, the canonical role of AIFM2 in apoptosis remained inconclusive until more recent discoveries redefined its function as a key suppressor of ferroptosis

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10.1046/j.1432-1327.1998.2510382.x Eur J Biochem

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demonstrated that CD4 + T cells in PD patients specifically recognize -Syn epitopes, triggering FAS receptor-mediated apoptotic signaling and increased secretion of inflammatory mediators, including IL-10