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Such discrimination in cell killing may lead to reduction in on-target off-tumour toxicity in healthy tissue displaying lower levels of the target antigen, leading to an increased therapeutic window similar to affinity tuning explored for CAR-T cells 37

The decrease in paw edema by cardamomin was suggested to be related to the reduction in the levels of COX-2, NO, TNF-, MDA, IL-1, IL-6, and iNOS in the paw edema

Classically, the posterior columns and corticospinal tracts of the spinal cord are affected, and hence the name combined systems degeneration

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