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In addition to these conventional approaches, experimental research has produced transgenic lines that express genes for resistance to pests and pathogens (Sokolova et al., 2024), plants with tolerance to salinity or drought through the overexpression of transcription factors such as AhDOF-AI or AhNF-YC (Priyadarsini et al., 2025), and transgenic roots obtained through Agrobacterium rhizogenes that produce secondary metabolites of industrial or nutraceutical interest (Sokolova et al., 2024)

Keywords: Acanthosis nigricans, insulin resistance, obesity INTRODUCTION Acanthosis nigricans (AN) is characterized by dark, coarse and thickened skin with a velvety texture, being symmetrically distributed on the neck, the axillae, antecubital and popliteal fossae, and groin folds, histopathologically characterized by papillomatosis and hyperkeratosis of the skin