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A new wrinkle on old skin: the role of elastic fibres in skin ageing

Novel mechanisms, such as microbiome dysbiosis and apolipoprotein L1 gene mutation, have improved our understanding of kidney disease mechanisms

Cells that are defective in KEAP1 have increased NRF2 transcription and increased import of cystine and export of glutamate, thus requiring more import of glutamine from the milieu to regenerate intracellular glutamate via glutaminase activity

For example, the collagen IV NC1 domain fragments canstatin (Kamphaus et al., 2000) and arresten (Nyberg et al., 2008) are anti-angiogenic, tumour suppressive and able to regulate apoptosis

Diet: Focus on sulfur-rich foods like garlic, onions, broccoli, Brussels sprouts, and protein sources such as fish and eggs

PG2, Prostaglandin F2