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[DOI] [PubMed] [Google Scholar] 123.Guillot A, Ren T, Jourdan T, Pawlosky RJ, Han E, Kim SJ, Zhang L, Koob GF, Gao B

Conditions such as malnutrition, alcoholism, certain medical conditions (e.g., Crohns disease, celiac disease), or restrictive diets (e.g., veganism without adequate supplementation for *B12*) can lead to deficiencies in one or more of these crucial vitamins

An additional observation is that in normal physiological conditions, glutamate is maintained at low levels in the brain

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Vitamin B12 also plays a role in the creation of serotonin